Good ol' rickets-preventing vitamin D turns out to be much more significant than once thought.  In fact, it influences over 200 genes and directly highlights links to major diseases:

The researchers found 2,776 binding sites for the vitamin D receptor along the length of the genome. These were unusually concentrated near a number of genes associated with susceptibility to autoimmune conditions such as MS, Crohn's disease, systemic lupus erythematosus (or 'lupus') and rheumatoid arthritis, and to cancers such as chronic lymphocytic leukaemia and colorectal cancer.

They also showed that vitamin D had a significant effect on the activity of 229 genes including IRF8, previously associated with MS, and PTPN2, associated with Crohn's disease and type 1 diabetes.

I take a quality vitamin D supplement every day.  I recommend Designs for Health's Vitamin D Supreme.  It's a top quality brand led and managed by some of the brightest folks in the field.

The Washington Post actually has a very good calculator.  Given my information, I will see no change in my coverage nor will I pay any additional taxes.

David Frum, noted Republican and conservative, is being linked around the web right now, and for good cause: he's being the most reasonable and making the most sense of any GOP voice out there.  Instead of vandalism on Democratic offices or alarmist cries of socialist monstrosties curbing American freedom, Frum puts a great deal of blame for the bill's formation and substance on conservatives like himself:

A huge part of the blame for today’s disaster attaches to conservatives and Republicans ourselves.

At the beginning of this process we made a strategic decision: unlike, say, Democrats in 2001 when President Bush proposed his first tax cut, we would make no deal with the administration. No negotiations, no compromise, nothing. We were going for all the marbles. This would be Obama’s Waterloo – just as healthcare was Clinton’s in 1994.

Only, the hardliners overlooked a few key facts: Obama was elected with 53% of the vote, not Clinton’s 42%. The liberal block within the Democratic congressional caucus is bigger and stronger than it was in 1993-94. And of course the Democrats also remember their history, and also remember the consequences of their 1994 failure.

This time, when we went for all the marbles, we ended with none.

Could a deal have been reached? Who knows? But we do know that the gap between this plan and traditional Republican ideas is not very big. The Obama plan has a broad family resemblance to Mitt Romney’s Massachusetts plan. It builds on ideas developed at the Heritage Foundation in the early 1990s that formed the basis for Republican counter-proposals to Clintoncare in 1993-1994.

Barack Obama badly wanted Republican votes for his plan. Could we have leveraged his desire to align the plan more closely with conservative views? To finance it without redistributive taxes on productive enterprise – without weighing so heavily on small business – without expanding Medicaid? Too late now. They are all the law.

The electoral-politics aspect of what just happened with health care is a bit strange.  It seems to me that the Republicans capitulated entirely to Tea Party sentiment, a move that sets them up for a Sarah Palin candidacy in 2012, which in turn is a move that sets them up for a crushing general-election defeat. Meanwhile the Democrats spent the health care debate fleeing from their own base, a move that… well, I don’t know what it means, exactly, but it does make me a little ill. The whole picture is strange: Democrats running as Republicans, Republicans running as Turner-Diaries conspiracy theorists.

I don’t get what the Republicans have to gain by painting themselves as hysterical survivalist Ruby-Ridge loonies (Kentucky congressman Geoff Davis pulling out the “Don’t Tread on Me” flag was a move more larded with mawkish over-drama than your average drag-queen tribute to Edith Piaf). It feels to me like they played this one wrong.

It doesn’t matter, though. Should I decide to change my politics and become a conservative now that I’m exactly the middle-aged bourgeois/suburban tool I used to rail against, I can always vote Republican by voting Democratic. The new Democratic Party is an excellent substitute for the old Nixon/Ford Republican Party. They even passed Nixon’s vision of a health care plan. That there’s no Democratic Party left is a shame, but I guess one choice is better than none.

Do not believe anyone who tells you they understand the path American politics will take after this vote. It is truly unique. And yet a few things are clear. One, the idea of the "pro-life" Democrat should be tossed into the dust-heap along with such outmoded concepts as cold-fusion. Two, Obama will achieve a short-term bump in his political capital, and likely his poll ratings, because he will have achieved something that every Democratic president since Harry Truman has been unable to accomplish. And three, Obamacare is a testable proposition. The proponents of this legislation have made distinct claims regarding its costs and consequences that should not be forgotten -- especially when America encounters its first debt crisis some years from now.

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For now, the significance of the vote is moving the United States FROM a system in which people can assume they will have health coverage IF they are old enough (Medicare), poor enough (Medicaid), fortunate enough (working for an employer that offers coverage, or able themselves to bear expenses), or in some other way specially positioned (veterans; elected officials)... TOWARD a system in which people can assume they will have health-care coverage. Period.

That is how the entire rest of the developed world operates, as noted yesterday. It is the way the United States operates in most realms other than health coverage. Of course all older people are eligible for Medicare. Of course all drivers must have auto insurance. Of course all children must have a public school they can attend. Etc. Such "of course" rules offer protection for individuals but even more important, they reduce the overall costs to society, compared with one in which extreme risks are uncontained.

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People forget how unpopular Reagan was at the same point in his presidency — and passing a big tax cut was legislatively a lot easier than reforming a health sector the size of the British economy. But like Obama he persisted and, with luck and learning, aimed very high.

Obama has bet that this is his destiny. He is extremely cautious from day to day, staggeringly flexible on tactics, but not at all modest when you look at the big picture.

He still wants to rebuild the American economy from the ground up, re-regulate Wall Street, withdraw from Iraq, win in Afghanistan, get universal health insurance and achieve a two-state solution in Israel/Palestine in his first term. That’s all. And although you can see many small failures on the way, and agonising slowness as well, you can also see he hasn’t dropped his determination to achieve it all.

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The story of bottled water, broken down to its basics.

(Via DF)

Tom Jefferson, an epidemiologist with the distinguished Cochrane Collaboration in the Britain, explains that we don’t really know what protection flu vaccines offer. Fascinating interview.

But, getting to the key question: What should people do to prevent the flu?

If they want to base it on good evidence, they should wash their hands.

Salon's Andrew Leonard:

It's amazing the effect Wal-Mart can have on entire industries.  And headlines like this one, among many others, are why I will only eat fresh caught/wild salmon.  I won't touch the farmed stuff.